Metabolism & incretins
Tirzepatide
Also known as: GIP/GLP-1-RA, Mounjaro
A dual GIP/GLP-1 receptor agonist, approved in the EU as Mounjaro. In clinical trials tirzepatide outperformed GLP-1-only agonists in weight management and glucose control.
Structure
- Molecular formula
- C₂₂₅H₃₄₈N₄₈O₆₈
- Molecular weight
- 4,813 Da
- Amino acids
- 39
- Half-life
- ~5 days
Mechanism of action
Tirzepatide activates both the GIP and GLP-1 receptors. The dual activation enhances insulin secretion, improves insulin sensitivity and modulates appetite and energy expenditure.
Studies
More in Metabolism & incretins
More detail (research areas, comparisons, FAQ): German lexicon entry.