Metabolism & incretins
Orforglipron
Also known as: LY3502970
An oral, non-peptide GLP-1 receptor agonist developed by Eli Lilly, taken as a daily tablet.
Structure
- Molecular formula
- C₃₀H₃₃F₃N₆O₅
- Molecular weight
- 614.6 Da
- Amino acids
- —
- Half-life
- ~24–36 hours
Mechanism of action
Orforglipron binds the GLP-1 receptor as a small molecule and activates the same intracellular signalling as native GLP-1. Its non-peptide structure allows oral absorption and stability in stomach acid.
Studies
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More detail (research areas, comparisons, FAQ): German lexicon entry.