Longevity
5 Amino 1MQ
Also known as: 5-Amino-1-Methylquinolinium, NNMT-Inhibitor
A small-molecule, selective inhibitor of nicotinamide N-methyltransferase (NNMT). Technically not a peptide, it is often discussed alongside peptides because of its role in longevity and metabolism research.
Structure
- Sequence
- Kein Peptid – Small Molecule
- Molecular formula
- C₁₀H₁₁N₂⁺
- Molecular weight
- 159.21 g/mol
- Amino acids
- n/a
- Half-life
- In Untersuchung – experimentell
Mechanism of action
5-Amino-1MQ inhibits NNMT, an enzyme that methylates nicotinamide and so affects the NAD+ salvage pathway. In preclinical models, NNMT inhibition raises intracellular NAD+ and SAM levels, with effects on fat cell differentiation, mitochondrial function and muscle regeneration.
Studies
More in Longevity
More detail (research areas, comparisons, FAQ): German lexicon entry.